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EC number: 203-137-6 | CAS number: 103-71-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Principles of method if other than guideline:
- Five or ten male or female Wister rats were treated semiocclusive with 100, 500, 2500, 3500 or 5000 µl/kg phenyl isocyanate for 24 hours. The animals were observed for mortality, body weight and clinical signs through day 14. A gross pathological examination was performed on animals which died intercurrent or were killed after termination of the study.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Phenyl isocyanate
- EC Number:
- 203-137-6
- EC Name:
- Phenyl isocyanate
- Cas Number:
- 103-71-9
- Molecular formula:
- C7H5NO
- IUPAC Name:
- isocyanatobenzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: cellulose powder
- Duration of exposure:
- 24 hours
- Doses:
- 100, 500, 2500, 3500 or 5000 µl/kg = ca. 109.5, 547.5, 2737.5, 3832.5, 5475 mg/kg
density = 1,095 kg/L (20 °C) according LXS MSDS - No. of animals per sex per dose:
- 5 or 10 male or female animals/dose
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Males: 0 (100 µl/kg bw), 0 (500 µl/kg bw), 0 (2500 µl/kg bw), 2 (3500 µl/kg bw), 6 (5000 µl/kg bw)
Females: 0 (100 µl/kg bw), 0 (500 µl/kg bw), 0 (2500 µl/kg bw), 1 (3500 µl/kg bw), 2 (5000 µl/kg bw) - Clinical signs:
- other: Immediately sensation of pain, decreased motility, closed eye lids, aggresivity (only males), laboured breathing, weakness of hind limbs, partly strong weight loss. Start of the symptoms: immediately to 15 minutes after application. Duration of the sympto
- Gross pathology:
- Necropsy findings on animals died intercurrent: lung was inflated and mottled, renal pelvis partly reddened, digestive tract normally without content.
Necropsy findings on animals killed after post-observation period: in the lethal dose range lungs were inflated, other internal organs macroscopically without findings.
Any other information on results incl. tables
Immediately sensation of pain, decreased motility, closed eye lids, aggresivity (only males), laboured breathing, weakness of hind limbs, partly strong weight loss.
Start of the symptoms: immediately to 15 minutes after application. Duration of the symptoms: during the observation period.
Necropsy findings on animals died intercurrent: lung was inflated and mottled, renal pelvis partly reddened, digestive tract normally without content.
Necropsy findings on animals killed after post-observation period: in the lethal dose range lungs were inflated, other internal organs macroscopically without findings.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 was > 5000 mg/kg bw (rat, male + female). According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is therefore not justified.
- Executive summary:
Five or ten male or female Wister rats were treated semiocclusive with 100, 500, 2500, 3500 or 5000 µl/kg phenyl isocyanate for 24 hours. The animals were observed for mortality, body weight and clinical signs through day 14. A gross pathological examination was performed on animals which died intercurrent or were killed after termination of the study.
LD50 > 5000 mg/kg bw (rat, male + female).
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