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EC number: 203-137-6 | CAS number: 103-71-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Fish
The acute toxicity to fish was measured of the hydrolysis product anilin in a flow-through study yielding a LC50 of 10.6 mg/L.
The long-term toxicity to fish (pimephales promelas) of the hydrolysis product aniline was measured during 32 days and a NOEC of 0.39 mg/L was obtained.
Daphnia
Short-term toxicity to aquatic invertebrates (Daphnia magna) of the hydrolysis product aniline was measured during 48 hours and showed an EC50 of 0.16 mg/L.
Due to the rapid hydrolysis of the substance, long-term toxicity results
for aquatic invertebrates of the hydrolysis product aniline is taken
into account for assessment. Three results are available:
Daphnia magna: NOEC (21d) = 0.016 mg/L
Daphnia magna: NOEC (21d) = 0.004 mg/L
Daphnia magna: NOEC (21d) = 0.024 mg/L .
Three Daphnia long-term tests are available that are regarded of equal
value. The lowest of the three NOECs results in a value of 4 μg/L.
Algae:
The toxicity to aquatic algae (chlorella pyrenoidosa) of the hydrolysis product aniline was tested according to OECD guideline 201 "Alga, Growth Inhibition Test, 1984". During 72 hours an EC50 of 175 mg/L and a NOEC of 90 mg/L was shown.
Microorganisms
Due to the rapid hydrolysis of phenyl isocyanate, results from the
hydrolysis product aniline are also taken into account for assessment.
In order to protect the efficiency of domestic and industrial waste
water treatment plants, inhibition of nitrification by the hydrolysis
product aniline is identified to be the most sensitive test system.
Nitrification inhibition was measured on activated sludge determined
according to ISO DIS 9509 (Method for Assessing the Inhibition of
Nitrification of Activated Sludge Microorganisms by Chemicals and Waste
Waters). An EC50 of 7 mg/l and and a NOEC of 2 mg/L was determined after
2 hours incubation.
Additional information
As phenyl isocyanate hydrolysis rapidly the results of the hydrolysis compound aniline are taken into account based on the following assumption:
According to handbook data, isocyanates react rapidly with water forming aminic structures as well as carbamic acids, which are mostly unstable, and ureas under release of carbon dioxide. Monitoring the amine formation in hydrolysis studies gives a picture of the degradation of the isocyanate. This behaviour of isocyanates has been used in studies to determine the rate of degradation*. In Guidance on IR & CSA Chapter R.6 it is mentioned that degradation products instead of parent substance can be investigated for ecotoxicological effects if the hydrolysis is very rapidly (t1/2 <1 h), OECD Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures (2000) and Guidance on IR & CSA Chapter R.7b state the same. As phenyl isocyanate hydrolyses to aniline this is the ecotoxicological relevant species. Concluding, tests performed using the corresponding amine can equally be used to assess the ecotoxicological hazards of phenyl isocyanate. An underestimation of environmental hazards is thus avoided supporting a conservative and thus protective hazard assessment.
* Bayer Industry Services (2004), 4-chlorophenyl-isocyanate: Investigation on Stability in Aqueous Test Solutions. Project No: 200300181. Leverkusen, Germany.
Bayer Industry Services (2003), Isopropyl isocyanate: Investigation on Stability in Aqueous Test Solutions. Project No: 200300095. Leverkusen, Germany.
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