Registration Dossier
Registration Dossier
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EC number: 203-581-0 | CAS number: 108-42-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
From the data available on the absorption, distribution, metabolism and elimination (excretion) of 3-chloroaniline in rats and rabbit, it can be concluded that the chemical is unlikely to exhibit bio-accumulation potential (in low dose levels) within the living system.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
From the data available on absorption, metabolism and excretion of 3-Chloroaniline in rats, since the chemical was metabolized as well as rapidly excreted out of the living system in substantial proportions (depending upon the dose administered), it is concluded that 3-Chloroaniline shall have no bio-accumulation potential. Even in an in-vivo study with rabbits, the chemical was metabolized and excreted in the urine within 48 hours. Thus, it can be concluded that in low dose levels, (3-chloroaniline)is likely to have no bio-accumulation potential within the living system; though larger doses caused severe anorexia and were sometimes fatal.
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