Registration Dossier
Registration Dossier
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EC number: 690-796-1 | CAS number: 420-16-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Documentation insufficient for assessment. Original reference is in Russian. Its translation is available but is not detailed enough. Actually this study involves several species (rats, mice and guinea-pigs) and reported results do not precise for each finding which species is concerned. In this IUCLID, all findings are reported.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of boron fluoride
- Author:
- Kasparov AA and Kirij VG
- Year:
- 1 972
- Bibliographic source:
- Farmakol. Toksikol. 1972; 35(3): 369-372.
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Boron trifluoride
- EC Number:
- 231-569-5
- EC Name:
- Boron trifluoride
- Cas Number:
- 7637-07-2
- Molecular formula:
- BF3
- IUPAC Name:
- boron trifluoride
Constituent 1
Test animals
- Species:
- other: mouse, rat and guine-pigs
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Duration of exposure:
- > 2 - <= 4
- Remarks on duration:
- Rats and guinea-pigs were exposed for 4 h while mice were exposed for 2h.
- Concentrations:
- no data
- Details on study design:
- - Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 1 180 mg/m³ air
- 95% CL:
- 959 - <= 1 451
- Exp. duration:
- 4 h
- Remarks on result:
- other: rats
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 3 460 mg/m³ air
- 95% CL:
- 2 900 - <= 4 350
- Exp. duration:
- 2 h
- Remarks on result:
- other: mice
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 109 mg/m³ air
- 95% CL:
- 81.5 - 146.3
- Exp. duration:
- 4 h
- Remarks on result:
- other: guinea pigs
- Mortality:
- Animals exhibiting previous findings died within 24 hours.
- Clinical signs:
- other: A marked irritation of ocular mucosa and respiratory troubles were noted. First, turmoil was observed, then an oppression phase with motor coordination troubles occurred.
- Body weight:
- Not examined
- Gross pathology:
- Dead animals exhibited mucosal cynanosis, congestion of internal organs and encephalic vessels. Moreover, lung presented an increased weight and haemorraghes. Microscopic examination confirmed lung injuries (important oedema, alveolar septa destruction. Cardiac and hepatic dystrophy were also noted. Kidneys, spleen and brain exhibited congestion.
Applicant's summary and conclusion
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