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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Minimal experimental detail and documentation. Information available in a summary document only. Although studies were not conducted according to currently accepted protocols and did not follow GLP procedures, the studies followed acceptable procedures of the time and the results are valid.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report Date:
1977

Materials and methods

Principles of method if other than guideline:
No information available.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Details on test material:
Sample marking: 77-144, Dimyrcetol

The test material was an approximately equal mixture of 2,6-dimethyl-7-octene-2-ol (CAS 18479-58-8) and the formate ester (CAS 25279-09-8) (Research Institute for Fragrance Materials, Inc., database entry, 2010).

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No information available.

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No details available.
Doses:
2.56, 3.2, 4.0 or 5.0 g/kg bwt
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
No details available.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4.1 other: g/kg bwt
95% CL:
3.5 - 4.8
Mortality:
See Table 1.
Clinical signs:
2.56 g/kg: lethargy
3.2 g/kg: lethargy, piloerection, blood on nose
4.0 g/kg: lethargy, flaccid, ataxia
5.0 g/kg: diarrhea

Any other information on results incl. tables

Table 1: Acute Oral Toxicity in the Rat - Mortality

Dose Levels (g/kg bwt)

Mortality, total

Day of Death

0

1

2

3

6

9

11

2.56

1/10

1

3.2

3/10

2

1

4.0

4/10

2

1

5.0

8/10

1

5

2

Table 2: Acute Oral Toxicity in the Rat - Clinical Signs and Necropsy Findings

Dose Levels (at death/sacrifice)

2.56

2.56

3.2

3.2

4.0

4.0

5.0

5.0

Necropsy Observations

Death

Sacr

Death

Sacr

Death

Sacr

Death

Sacr

Normal

3

1

Exudate, nose/mouth

3

7

Lungs - dark

1

white nodules

2

dark areas

2

4

6

6

2

Liver - dark

1

1

1

4

mottled

3

2

2

3

Kidneys - dark

2

mottled

1

Skin - edema

hairless

Intestines - red areas

2

3

6

orange areas

1

1

1

Stomach - red areas

2

3

Spleen - large

2

2

1

dark

1

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information
Conclusions:
The LD50 value for dimyrcetol in the rat following oral gavage administration was 4.1 g/kg bwt. Signs of toxicity described in some animals in this study included lethargy, piloerection, blood on the nose, flaccidity, ataxia, and diarrhea.