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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Although studies were not conducted according to currently accepted protocols and did not follow GLP procedures, the studies were conducted according to acceptable procedures of the time and the results are valid.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report Date:
1977

Materials and methods

Principles of method if other than guideline:
No information available
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Details on test material:
Sample marking: 77-144, Dimyrcetol

The test material was an approximately equal mixture of 2,6-dimethyl-7-octene-2-ol (CAS 18479-58-8) and the formate ester (CAS 25279-09-8) (Research Institute for Fragrance Materials, Inc., database entry, 2010).

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No information provided

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
No information available
Duration of exposure:
Presumably 14 days
Doses:
5.0 g/kg bwt
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
Presumably, animals were observed for mortality and clinical signs for 14 days.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 other: g/kg bwt
Mortality:
Mortality was 2 of 10 rabbits on days 2 and 6.
Clinical signs:
Clinical signs included severe erythema and mild to severe edema.
Gross pathology:
The following necropsy observations (with incidence) were recorded:
Lungs, dark, 2/5
Liver, dark, 1/5
Liver, mottled, 2/5
Kidney, dark, 1/5
Skin, edema, 2/5
Skin, hairless, 3/5
Intestines, red area, 1/5

Applicant's summary and conclusion

Conclusions:
The acute dermal LD50 was greater than 5.0 g/kg bwt.