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EC number: 203-080-7 | CAS number: 103-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Basic data given: scientifically acceptable study summary including result tabels; the test protocol can be viewed online. The quality of the NTP studies is generally good and accepted within the toxicological community. Neither Escherichia coli strain WP2 uvrA pKM101a nor S. typhimurium strain TA102 were employed in this study for the detection of oxidising mutagens and cross-linking agents.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
- Reference Type:
- publication
- Title:
- Mutagenicity Testing of Di(2-ethylhexyl)phthalate and Related Chemicals in Salmonella.
- Author:
- Zeiger E et al.
- Year:
- 1 985
- Bibliographic source:
- Environ. Mutagenesis 7: 213-232
Materials and methods
- Principles of method if other than guideline:
- The study was conducted according to the Standard NTP protocol (Preincubation Assay) which is comparable to the method described in the publication by Mortelsman and Zeiger (2000).
Mortelmans K, Zeiger E (2000). The Ames Salmonella/microsome mutagenicity assay. Mutat Res. 455(1-2): 29-60 - GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2-ethylhexyl acrylate
- EC Number:
- 203-080-7
- EC Name:
- 2-ethylhexyl acrylate
- Cas Number:
- 103-11-7
- Molecular formula:
- C11H20O2
- IUPAC Name:
- 2-ethylhexyl acrylate
- Details on test material:
- - Test substance: 2-ethylhexyl acrylate
- Chemical name: 2-propenoic acid, 2-ethylhexyl ester
- CAS No.: 103-11-7
- Analytical Purity: no data
Constituent 1
Method
- Target gene:
- Histidin auxotrophy
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 from Aroclor 1254-induced male Sprague-Dawley rat and Syrian hamster liver
- Test concentrations with justification for top dose:
- 0, 3.3, 10, 33, 100, 333, 1000, 3333, 10000 ug/plate
- Vehicle / solvent:
- dimethylsulfoxide
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- dimethylsulfoxide
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: Without activation: for TA1535 sodium azide, for TA100 sodium azide, for TA98 4-nitrophenylenediamine, for TA1537 9-aminoacridine; With activation: for all strains 2-aminoanthracene
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: preincubation
METABOLIC ACTIVATION
The test was conducted with and without metabolic activation. In this study metabolic activation enzymes and cofactors from Aroclor 1254 -induced male Sprague-Dawley rat and Syrian hamster liver were used. The percentage of S9 in the S9 mixture that was then added to cultures, was 10 %.
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- other: TA1537: 333 ug/plate; TA1535 and TA100: 10000 ug/plate
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
Any other information on results incl. tables
TA1535:
Mean number of revertants
Dose No activation 10 % HLI 10 % RLI
[ug/plate] 1st 2nd 1st 2nd 1st 2nd
--------------------------------------------------------------
0 13 30 13 23 8 19
100 11 23 12 18 13 21
333 9 22 11 15 9 20
1000 11 25 10 17 8 26
3333 13 20 8 14 9 24
10000 T T T 17 T 17
Pos. control 1071 1114 201 439 552 537
--------------------------------------------------------------
TA100:
Mean number of revertants
Dose No activation 10 % HLI 10 % RLI
[ug/plate] 1st 2nd 1st 2nd 1st 2nd
--------------------------------------------------------------
0 130 166 159 238 164 193
100 138 171 118 255 134 227
333 126 163 103 223 165 202
1000 115 153 114 178 159 217
3333 112 152 108 183 176 193
10000 T 144 75 189 152 178
Pos. control 1632 358 1320 1321 906 2114
--------------------------------------------------------------
TA98:
Mean number of revertants
Dose No activation 10 % HLI 10 % RLI
[ug/plate] 1st 2nd 1st 2nd 1st 2nd
--------------------------------------------------------------
0 19 15 28 33 27 21
100 15 15 31 33 21 28
333 14 14 26 33 25 28
1000 13 13 23 32 21 25
3333 16 10 21 31 17 25
10000 18 9 19 22 16 22
Pos. control 572 430 1058 924 1069 2119
--------------------------------------------------------------
TA1537:
Mean number of revertants
Dose No activation 10 % HLI 10 % RLI
[ug/plate] 1st 2nd 3rd 1st 2nd 1st 2nd
---------------------------------------------------------------------
0 9 9 14 12 29 11 26
3.3 11 13
10 9 12
33 5 4
100 7 5 8 15 22 11 23
333 T T T 7 19 10 17
1000 T 7 15 13 19
3333 T 9 18 9 14
10000 T 6 19 8 14
Pos. control 199 730 1000 1341 413 382 196
---------------------------------------------------------------------
RLI: Rat Liver S9
HLI: Hamster Liver S9
s: slight toxicity
T: Toxic
Applicant's summary and conclusion
- Conclusions:
- negative
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