2-ethylhexyl acrylate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given: scientifically acceptable study report

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1958

Report date:

1958

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

BASF test (inhalation hazard test)

GLP compliance:

no

Test type:

other: Inhalation hazard test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexyl acrylate

EC Number:

203-080-7

EC Name:

2-ethylhexyl acrylate

Cas Number:

103-11-7

Molecular formula:

C11H20O2

IUPAC Name:

2-ethylhexyl acrylate

Details on test material:

- Test substance: 2-ethylhexyl acrylate
- Chemical name: 2-propenoic acid, 2-ethylhexyl ester
- Analytical Purity: no data
- Impurities: stabilised with 0.05 % hydrochinone
- Density: 0.887 g/cm3 (DIN 51757, cited in EU RAR, 2005)

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS

- Weight at study initiation: 884 g (mean)

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

1.19 mg/L

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

The vapour saturation was calculated based on the vapour pressure at 25 °C and the molecular weight.
Vapour saturation = 1.82 mg/L at 25 °C.
The assumed vapour saturation at the test temperature of 20 °C would be slightly lower than the calculated value but still greater than 1 mg/L. Thus, it can be safely concluded that the animals in the present study were indeed exposed to test substance vapours and no aerosol.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

> 1.19 mg/L air (nominal)

Exp. duration:

8 h

Remarks on result:

other: IHT, saturated vapor concentration

Mortality:

No mortality was observed when 6 rats were exposed for 8 hours to an atmosphere that had been saturated at 20°C with the volatile parts of the compound.

Clinical signs:

other: No clinical signs were noted during the test.

Body weight:

Body weights increased continuously.

Gross pathology:

Since the test animals showed neither clinical signs nor other abnormalities, the necropsy was omitted.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Executive summary:

In an inhalation hazard test, several groups of 3 rats per sex were exposed sequentially to the vapors, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder containing approximately 120 mL of 2-EHA (stabilised with 0.05% hydroquinone, no data on purity) for 8 hours. Compressed air without further filtering was used in order to generate the test substance atmosphere. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during the exposure, which was given in the raw data, and the amount of air used during the exposure. Group-wise documentation of clinical signs was performed over the 14-day study period. Body weight of groups was determined before the start of the study and at the end of the observation period in the surviving animals. The clinical signs and findings were reported in summarized form. The study allows for an estimate of the length of time required to cause severe toxic effects resulting from exposure to an atmosphere saturated  with volatile components of the test substance. No mortality and no clinical signs were observed in 6 animals, no more details are given.