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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1946
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Cross-reference
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
not given
Author:
Anonymus
Year:
1946
Bibliographic source:
British Journal of Pharmacology and Chemotherapy. Vol. 1, Pg. 186, 1946

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Public available literature. No guideline indicated. For details on method see materials and methods section.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
not indicated.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not indicated.

Administration / exposure

Route of administration:
intramuscular
Vehicle:
not specified
Details on exposure:
not indicated.
Doses:
not indicated.
No. of animals per sex per dose:
not indicated.
Control animals:
not specified
Details on study design:
not indicated.
Statistics:
not indicated.

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LC50
Effect level:
310 mg/kg bw
Mortality:
not indicated.
Clinical signs:
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - convulsions or effect on seizure threshold
Kidney/Ureter/Bladder - urine volume increased
Body weight:
not indicated.
Gross pathology:
not indicated.
Other findings:
not indicated.

Applicant's summary and conclusion

Conclusions:
LD50 (mice, intramuscular administration) = 310 mg/kg bw.
Executive summary:

In an acute toxicity study (intramuscular administration), groups of mice were given doses of sodium cyanate.

LD50 = 310 mg/kg bw

Clinical signs:

Behavioral - altered sleep time (including change in righting reflex)

Behavioral - convulsions or effect on seizure threshold

Kidney/Ureter/Bladder - urine volume increased