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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Review article only. Read across to sodium cyanate. For justification of read across see endpoint summary.
Cross-reference
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
review article or handbook
Title:
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inorganic substances containing I-IV group elements)
Author:
Filov V.A.
Year:
1988
Bibliographic source:
Chimia, 1988, page 351

Materials and methods

Study type:
not specified
Endpoint addressed:
repeated dose toxicity: oral
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Public available literature. No guideline indicated. For details on method see materials and methods section.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Type of population:
not specified
Ethical approval:
not specified
Route of exposure:
other: unreported, most probably oral
Reason of exposure:
other: no data, most probably intentional
Exposure assessment:
not specified
Details on exposure:
duration of exposure: 26 weeks

Results and discussion

Clinical signs:
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
TDLo - Lowest published toxic dose = 5475 mg/kg/ 26 weeks equivalent to 30 mg/kg bw/day (intermittent)

Applicant's summary and conclusion

Conclusions:
TDLo - Lowest published toxic dose (human) = 5475 mg/kg/26 weeks equivalent to 25 mg/kg bw/day (intermittent)
Executive summary:

In a 26 weeks human study sodium cyanate was administered most probably oral.

Effects observed:

Sense Organs and Special Senses (Eye) - effect, not otherwise specified

TDLo - Lowest published toxic dose = 5475 mg/kg/26 weeks equivalent to 25 mg/kg bw/day (intermittent)

This study in humans is acceptable as supporting study.