Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-030-6 | CAS number: 917-61-3
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Review article only. Read across to sodium cyanate. For justification of read across see endpoint summary.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inorganic substances containing I-IV group elements)
- Author:
- Filov V.A.
- Year:
- 1 988
- Bibliographic source:
- Chimia, 1988, page 351
Materials and methods
- Study type:
- not specified
- Endpoint addressed:
- repeated dose toxicity: oral
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Public available literature. No guideline indicated. For details on method see materials and methods section.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium cyanate
- EC Number:
- 213-030-6
- EC Name:
- Sodium cyanate
- Cas Number:
- 917-61-3
- Molecular formula:
- CNO.Na
- IUPAC Name:
- sodium cyanate
Constituent 1
Method
- Type of population:
- not specified
- Ethical approval:
- not specified
- Route of exposure:
- other: unreported, most probably oral
- Reason of exposure:
- other: no data, most probably intentional
- Exposure assessment:
- not specified
- Details on exposure:
- duration of exposure: 26 weeks
Results and discussion
- Clinical signs:
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified
TDLo - Lowest published toxic dose = 5475 mg/kg/ 26 weeks equivalent to 30 mg/kg bw/day (intermittent)
Applicant's summary and conclusion
- Conclusions:
- TDLo - Lowest published toxic dose (human) = 5475 mg/kg/26 weeks equivalent to 25 mg/kg bw/day (intermittent)
- Executive summary:
In a 26 weeks human study sodium cyanate was administered most probably oral.
Effects observed:
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
TDLo - Lowest published toxic dose = 5475 mg/kg/26 weeks equivalent to 25 mg/kg bw/day (intermittent)
This study in humans is acceptable as supporting study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
