Registration Dossier
Registration Dossier
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EC number: 229-633-2 | CAS number: 6635-20-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Monsanto Chemical Company, USA
- Year:
- 1 995
- Bibliographic source:
- Younger Laboratories Inc. 1976. Report no. Y-76-261
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Vanillin
- EC Number:
- 204-465-2
- EC Name:
- Vanillin
- Cas Number:
- 121-33-5
- Molecular formula:
- C8H8O3
- IUPAC Name:
- 1-butoxypropan-2-ol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- corn oil
- Details on dermal exposure:
- Vehicle:
- Concentration: 40% - Duration of exposure:
- 24 hours
- Doses:
- 7160, 5010 and 7940 mg/kg bw
- No. of animals per sex per dose:
- 1 animal (male or female) per concentration
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 010 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality after 14 days at 3160 and 5010 mg/kg.
Mortality after 3 days at 7940 mg/kg.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The lethal dose (LD50 ) value of vanillin on rabbit was found to be >5010 mg/kg.
- Executive summary:
The lethal dose (LD50 ) value of vanillin on rabbit was found to be >5010 mg/kg.
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