Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Additional information

Justification for classification or non-classification

The acute oral LD50 for Diethylene Glycol Diethyl Ether is 4970mg/kg bw in male rats and 3674.3mg/kg bw in female mice.

The acute dermal LD50 values for Diethylene Glycol Ethyl Ether and Diethylene Glycol Methyl Ethyl Ether are 6000 and 6420mg/kg bw in rats, respectively. These two substances are used as read across for the classification of acute dermal toxicity of DEGDEE (see Category Approach-Read across Bis(2 -ethoxyethyl)ether, 2013).

The acute inhalation LC50 of diethylene glycol dimethyl ether in rats after 7 h inhalation exposure is >11 mg/L (saturated atmosphere).The acute dermal LD50 value for Diethylene Glycol Ethyl Ether is >5.24 mg/L (mists) in rats. These two substances are used as read across for the classification of acute toxicity of DEGDEE by the inhalation route (see Category Approach-Read across Bis(2 -ethoxyethyl)ether, 2013).

Based on these results, DEGDEE is not classified as acutely toxic according to CLP criteria (Regulation (EC) No 1272/2008).