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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vitro / ex vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Study run to a reliable method but not to GLP and no guideline followed. However it is a peer-reviewed publication.The restriction is also due to the use of the category read accross approach. study was performed not with DEGDEE but with DEGDME, a substance which like DEGDEE is part of the diethylene glycol monoalkyl and dialkyl ethers category. These substances have been demonstrated to be similar in structure, physical/chemical properties and toxicological profile.

Data source

Reference
Reference Type:
publication
Title:
Skin Absorption in vitro of glycol ethers
Author:
Larese Filon F, Fiorito A, Adami G, Barbieri P, Coccani N, Bussani R & Reisenhofer E.
Year:
1999
Bibliographic source:
International Archives of Occupational and Environmental Health, Vol 72 (1999)
Report Date:
1998

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
In vitro skin permeation using human skin was measured with the Franz method (Franz, 1975)
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Diethylene glycol dimethyl ether (DEGDME)
- Molecular formula (if other than submission substance): C6H14O3
- Molecular weight (if other than submission substance): 134
- Smiles notation (if other than submission substance): COCCOCCOC
- InChl (if other than submission substance): 1S/C6H14O3/c1-7-3-5-9-6-4-8-2/h3-6H2,1-2H3
- Structural formula attached as image file (if other than submission substance): see Fig.
- Substance type: organic
- Physical state: liquid
- Analytical purity: 99%
Radiolabelling:
no

Administration / exposure

Type of coverage:
open
Vehicle:
unchanged (no vehicle)
Duration of exposure:
One application of solvent to in vitro skin
Doses:
- Nominal doses: 0.2 mL

Results and discussion

Signs and symptoms of toxicity:
not examined
Dermal irritation:
not examined

Any other information on results incl. tables

Lag time for DEGDME was 36 ± 3 min. Flux at steady state for DEGDME was 0.952 ± 0.340 mg/cm2/h. The permeation rate for DEGDME was 1.016 ± 0.344 cm/h x 10 -3.

Applicant's summary and conclusion

Conclusions:
The high potential for skin absorption of glycol ethers is confirmed by the lag time for DEGDME of 36 minutes.
Executive summary:

DEGDEE and DEGDME, which is in the above study tested for its skin penetration rate through human skin, are both part of the diethylene glycol monoalkyl and dialkyl ethers category described and evaluated in the document titled "Category Approach-Read across Bis(2 -ethoxyethyl)ether" (2013).

These substances have been demonstrated to be very similar in structure, physical/chemical properties and toxicological profile . Therefore, a read-across from DEGDEE to data obtained with DEGDME is scientifically justified.