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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Study period:
1962 (Received for publication)
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Non GLP but peer reviewed publication. The restriction is also due to the use of read across approach: the study was performed not with DEGDEE but with DEGMEE, a substance which like DEGDEE is part of the diethylene glycol monoalkyl and dialkyl ethers category. These substances have been demonstrated to be similar in structure, physical/chemical properties and toxicological profile.

Data source

Reference
Reference Type:
publication
Title:
Industrial Hygiene Journal
Author:
Smyth H F, et al
Year:
1962
Bibliographic source:
Range-Finding Toxicity Data: List VI Volume 23, Number 1
Report Date:
1962

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
not specified

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source:
- Age at study initiation: 4 to 5 weeks
- Weight at study initiation: 90 to 120g
- Fasting period before study:
- Housing:
- Diet (e.g. ad libitum): Rockland rat diet
- Water (e.g. ad libitum):
- Acclimation period:

ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light):

IN-LIFE DATES: From: To:

Administration / exposure

Route of administration:
oral: gavage
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
The most probable LD50 value and its fiducial range are estimated by the method of Thompson using the Tables of Weil.

Thompson, W. R.: Use of Moving Average and Interpolation to Estimate Median Effective Dose. Bacteriol. Rev. 11: 115 (June 1947)
Weil, C. S.: Tables for Convenient Calculation of Median- Effective Dose (LD50 or ED50) and Instructions in Their Use. Biometrics 8: 249 (Sept. 1952).

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
6 500 mg/kg bw
Based on:
test mat.
95% CL:
> 4 950 - < 8 530

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 for diethylene glycol methyl ethyl ether was estimated to be 6500mg/kg bw in rats.
Executive summary:

DEGDEE and DEGMEE, which is in the above study tested for its acute oral toxicity in rats, are both part of the diethylene glycol monoalkyl and dialkyl ethers category described and evaluated in the document titled "Category Approach-Read across Bis(2 -ethoxyethyl)ether" (2013).

These substances have been demonstrated to be very similar in structure, physical/chemical properties and toxicological profile . Therefore, a read-across from DEGDEE to data obtained with DEGMEE is scientifically justified.