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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Study period:
1941 - 1946
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Study run to a reliable method but not to GLP and no guideline followed and limited information. However it is a peer-reviewed publication.The restriction is also due to the use of the category read accross approach. study was performed not with DEGDEE but with DEGEE, a substance which like DEGDEE is part of the diethylene glycol monoalkyl and dialkyl ethers category. These substances have been demonstrated to be similar in structure, physical/chemical properties and toxicological profile.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1947
Report Date:
1946

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): diethylene glycol monoethyl ether
- Molecular formula (if other than submission substance): C6H14O3
- Molecular weight (if other than submission substance): 134
- Smiles notation (if other than submission substance): OCCOCCOCC
- InChl (if other than submission substance): 1S/C6H14O3/c1-2-8-5-6-9-4-3-7/h7H,2-6H2,1H3
- Structural formula attached as image file (if other than submission substance): see Fig.
- Substance type:
- Physical state: liquid
- Analytical purity: specially prepared pure compound

Test animals

Species:
rat
Strain:
other: white
Sex:
not specified
Details on test animals and environmental conditions:
TEST ANIMALS
- Source:
- Age at study initiation:
- Weight at study initiation:
- Fasting period before study:
- Housing:
- Diet (e.g. ad libitum):
- Water (e.g. ad libitum):
- Acclimation period:

ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light):

IN-LIFE DATES: From: To:

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
Subcutaneous
Duration of exposure:
48 hrs
Doses:
1, 2, 4, 6, 8 mL/kg bw
No. of animals per sex per dose:
sex not stated but animal numbers as follows:
5 rats at 1 mL/kg bw,
10 rats at 2, 4 & 6 mL/kg bw,
9 rats at 8 mL/kg bw
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
6 mL/kg bw
Based on:
test mat.
Mortality:
0% at 1 mL/kg bw
10% at 2 mL/kg bw
20% at 4 mL/kg bw
50% at 6 mL/kg bw
100% at 8 mL/kg bw
Clinical signs:
Ataxia with an initial increase in respiration followed by a decrease. Some central nervous system depression, coma and death.
Gross pathology:
Grossly, the organs of all the animals used, and dying within forty-eight hours, appeared normal. With the highest doses hemolysis and hemoglobinuria were observed.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The LD50 for subcutaneous administration of diethylene glycol diethyl ether to white rats was 6 mL per kg bw
Executive summary:

DEGDEE and DEGEE, which is in the above study tested for its acute dermal toxicity in rats, are both part of the diethylene glycol monoalkyl and dialkyl ethers category described and evaluated in the document titled "Category Approach-Read across Bis(2 -ethoxyethyl)ether" (2013).

These substances have been demonstrated to be very similar in structure, physical/chemical properties and toxicological profile . Therefore, a read-across from DEGDEE to data obtained with DEGEE is scientifically justified.