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EC number: 229-222-8
CAS number: 6440-58-0
DMDMH readily undergoes hydrolysis to DMH and therefore data is provided for both substances. In the case of long term testing, the data on DMH is considered more relevant. In a 90 day study with DMH the NOAEL was >1000 mg/kg and in 90 day dermal study the NOEL was 390 mg/kg (limited by solubility).
DMDMH readily undergoes hydrolysis to DMH and therefore data is provided
for both substances. In the case of long term testing the data on DMH is
considered more relevant.
Following 90 days oral dosing of DMH at up to 1000 mg/kg for 90 days, no
significant toxicity was observed (NOAEL >1000 mg/kg). Following 90
days dermal dosing of DMH at up to 390 mg/kg (top dose limited by
solubility), no significant systemic or local toxicity was observed
(NOAEL = 390 mg/kg).
Following 28 days dermal dosing of DMDMH at up to 440 mg/kg, no
significant systemic toxicity was observed (NOAEL > 440 mg/kg) however
skin effects at the application site were observed.
The results from the various repeat dose studies on both DMDMH and DMH
do not meet the criteria for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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