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EC number: 229-222-8
CAS number: 6440-58-0
DMDMH readily undergoes hydrolysis to DMH and therefore data is provided for both substances. DMDMH is of low to moderate acute toxicity and DMH is of low acute toxicity.
The LD50 (rat, oral) for Glycoserve II = 2890mg/kg,
equivalent to LD50 (rat; oral) for DMDMH - 1572mg/kg.
The LD50 value for the Glycoserve II (52,6% DMDMH in aqueous solution)
is higher than 2000 mg/kg b.w., equivalent value for the active
substance (DMDMH) is 1052 mg/kg b.w.
DMDMH is of low to moderate acute toxicity in mammals. The acute oral
LD50 is reported in two different studies as 1572 and 2046 mg/kg
respectively while the dermal LD50 is above 1052 mg/kg. Testing by the
inhalation route is not scientifically justified.
The hydrolysis product DMH is of low acute toxicity in mammals. The
acute oral LD50 is 10000 - 20000 mg/kg and the dermal LD50 is above
the acute oral LD50 values, DMDMH is classified for acute toxicity by
the oral route. Following dermal dosing at up to 1052 mg/kg no mortalities
or signs of systemic toxicity were seen. Given that signs of toxicity
were seen at 1/5th of the LD50 value in the acute oral study, it is
concluded that the dermal LD50 lies significantly above 2000 mg/kg and
hence classification is not justified for the dermal route.
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