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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Description of key information

No reliable (Klimisch 1 or 2) long-term toxicity studies with invertebrates have been conducted for DMDMH, although a reliable (Klimisch 1) long-term toxicity study with invertebrates using DMH is included in this dossier. The study (Zelinka et al., 1993) provides an estimated NOEC of 70.9 mg/L based on reproduction and mortality. Consequently this value will be taken as the long-term toxicity in invertebrates endpoint for DMDMH. 

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
70.9 mg/L

Additional information

No reliable (Klimisch 1 or 2) long-term toxicity studies with invertebrates have been conducted for DMDMH. However, a reliable study has been conducted with the hydrolysis product of DMDMH, DMH, and is included in this dossier. DMDMH readily undergoes hydrolysis to DMH and therefore data are provided for both substances when available. In the case of long term testing, the data on DMH are considered more relevant for environmental fate and ecotoxicology and are considered in this dossier.

Zelinka et al. (1993)) conducted a reliable (Klimisch 1) GLP compliant study following OECD 202 methods using DMH, the hydrolysis product of DMDMH. Daphnia magna, <24 hrs old, were exposed to measured concentrations (15.7, 25.3, 42.2, 70.9, 116 mg/L) of DMH in flow-through system for 21 days. The 21-day NOEC, based on mortality and/or reproduction, was 70.9 mg/L and the LOEC, based on mortality was 116 mg/L.

 

This reliable study (Zelinka et al., 1993) provides an estimated NOEC of 70.9 mg/L based on reproduction and mortalityusing DMH and is considered to be representative of the long-term toxicity potential of DMDMH in aquatic invertebrates. The half-life of DMDMH is <1 day (pH 7) and it is considered scientifically unjustified to perform a long-term toxicity study using DMDMH.

 

No reliable (Klimisch 1 or 2) long-term toxicity studies with invertebrates have been conducted for DMDMH, although a reliable (Klimisch 1) long-term toxicity study with invertebrates using DMH is included in this dossier. The study (Zelinka et al., 1993) provides an estimated NOEC of 70.9 mg/L based on reproduction and mortality. Consequently this value will be taken as the long-term toxicity in invertebrates endpoint for DMDMH.