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Diss Factsheets
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EC number: 202-863-0 | CAS number: 100-54-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliable with restrictions; comparable to guideline study with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no information on method
- Principles of method if other than guideline:
- no information on method
- GLP compliance:
- no
- Test type:
- other: LD50
- Limit test:
- no
Test material
- Reference substance name:
- Nicotinonitrile
- EC Number:
- 202-863-0
- EC Name:
- Nicotinonitrile
- Cas Number:
- 100-54-9
- Molecular formula:
- C6H4N2
- IUPAC Name:
- pyridine-3-carbonitrile
- Reference substance name:
- Pyridine-3-carbonitrile
- IUPAC Name:
- Pyridine-3-carbonitrile
- Details on test material:
- Purity of Nicotinonitrile: not stated
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Sherman-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Rats weighed 200-300g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Rats were deprived of food, but not water, for 24 hours prior to dosing. Food and water were available ad libitum post dose.
- Doses:
- Concentrations of 250, 500, 1000, 2000 and 4000 mg/kg.
- No. of animals per sex per dose:
- Five male rats per group were dosed at 50% w/v suspension in water
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 100 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 960 - 1 500
- Mortality:
- 250 mg/kg = 0/5
500 mg/kg = 0/5
1000 mg/kg = 2/5 — within 24 hours, animals were semi-comatose, which prevaled for five days during which time two animals died, one at three days post dose and the other four days post dose.
2000 mg/kg = 5/5
4000 mg/kg = 5/5 - Clinical signs:
- other: No signs of toxicity were observed at the 250 mg/kg dose level. At 500 mg/kg, the rats were depressed one hour post dose and lethargic. They appeared normal 24 hours post dose.
- Gross pathology:
- Findings revealed nothing remarkable.
- Other findings:
- Rats in the 1000 mg/kg dose group were extremely depressed 30 minutes post dose and exhibited shallow breathing. Within 24 hours they were semi-comatose. The surviving rats appeared normal eight to nine days post dose. At 2000 mg/kg and 4000 mg/kg the animals died within 1-3 hours.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information LD50 > 300 mg/kg and < 2000 mg/kg Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of 3-cyanopyridine has been adequately characterized at 1100 mg/kg (95% Confidence limits = 960-1500 mg/kg)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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