p-vinylphenol

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

No data

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

GLP compliance:

yes

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Maruzen Petrochemical Co. Ltd.
- Expiration date of the lot/batch:
- Purity test date:

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material:
- Stability under test conditions:
- Solubility and stability of the test substance in the solvent/vehicle:
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium:

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing:
- Preliminary purification step (if any):
- Final dilution of a dissolved solid, stock liquid or gel:
- Final preparation of a solid:

Radiolabelling:

no

Analytical monitoring:

yes

Details on test conditions:

TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: 10mL glass test tube with a stopper
- Sterilisation method:
- Lighting: Light shielding conditions
- Measures taken to avoid photolytic effects:
- Measures to exclude oxygen:
- Details on test procedure for unstable compounds:
- Details of traps for volatile, if any
- If no traps were used, is the test system closed/open
- Is there any indication of the test material adsorbing to the walls of the test apparatus?
TEST MEDIUM
- Volume used/treatment:
- Kind and purity of water:
- Preparation of test medium:
- Renewal of test solution:
- Identity and concentration of co-solvent:
OTHER TEST CONDITIONS
- Adjustment of pH:
- Dissolved oxygen:

Duration:

5 d

pH:

4

Temp.:

50 °C

Initial conc. measured:

ca. 10 mg/L

Duration:

5 d

pH:

7

Temp.:

50 °C

Initial conc. measured:

ca. 10 mg/L

Duration:

5 d

pH:

9

Temp.:

50 °C

Initial conc. measured:

ca. 10 mg/L

Positive controls:

no

Negative controls:

no

Transformation products:

no

% Recovery:

78.7

pH:

4

Temp.:

50 °C

Duration:

5 d

% Recovery:

71.9

pH:

7

Temp.:

50 °C

Duration:

5 d

% Recovery:

88.2

pH:

9

Temp.:

50 °C

Duration:

5 d

Key result

Remarks on result:

not determinable because of methodological limitations

Validity criteria fulfilled:

not specified

Conclusions:

The results of this study must be treated with caution. The concentration of the test substance in the test solution decreased similarly at all pH's and factors other than hydrolysis were considered as the cause of these decreases. Furthermore, the test substance has the property of polymerising in a solvent. Taking these facts into consideration it is concluded that the test substance is polymerising in water and it is therefore difficult to evaluate the hydrolysability based on the measurement of concentration.

Description of key information

The results of this study must be treated with caution. The concentration of the test substance in the test solution decreased similarly at all pH's and factors other than hydrolysis were considered as the cause of these decreases. Furthermore, the test substance has the property of polymerising in a solvent. Taking these facts into consideration it is concluded that the test substance is polymerising in water and it is therefore difficult to evaluate the hydrolysability based on the measurement of concentration.