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EC number: 203-984-1 | CAS number: 112-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is classified as reliable with restriction because although it is a pre-guideline study, it is similar to current guidelines and therefore deemed sufficient to assess the acute toxicity of dodecane-1-thiol.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
- Principles of method if other than guideline:
- In a pre-guideline study, WBS/W rats (10 males) were administered 5000 mg/kg bw of dodecane-1-thiol (undiluted) by stomach tube. The animals were then observed for 14 days following exposure.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dodecane-1-thiol (CAS # 112-55-0)
- IUPAC Name:
- Dodecane-1-thiol (CAS # 112-55-0)
- Details on test material:
- - Name of test material (as cited in study report): n-dodecyl mercaptan (dodecane-1-thiol)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: WBS/W
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 5 000 mg/kg bw
- Remarks on result:
- other: Based on lack of mortality and systemic toxicity effects
- Mortality:
- No mortality was reported through the study period
- Clinical signs:
- other: No data reported.
- Gross pathology:
- No data reported.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information No mortalities were observed at 5000 mg/kg. Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 for dodecane-1-thiol is >= 5000 mg/kg bw.
- Executive summary:
In an acute toxicity study, male WBS/W rats (10/dose) were orally administered (via gavage) a single dose of 5000 mg/kg of dodecane-1-thiol by gavage. The animals were subsequently observed for a period of 14 days.
No mortalities were observed. All animals showed significant daily body weight losses for three to four days, which were recovered by six to eleven days after treatment. Based on the lack of mortality and treatment-related systemic toxicity efffects, the acute oral LD50 for dodecane-1-thiol was higher than 5000 mg/kg bw.
The study received a Klimisch score of 2 and is classified as reliable with restriction because although it is a pre-guideline study, it is similar to current guidelines and therefore deemed sufficient to assess the acute toxicity of dodecane-1-thiol.
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