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EC number: 231-900-3
CAS number: 7778-18-9
Table 1: Primary dermal irritation following application of 0.5 g of the
30 – 60 min
Interpretation of results:
The substance was classified according to the following scale, in
accordance with Guideline 83/467/CEE, Annex VI, part IIB.
A substance or preparation is considered irritant if the inflammation of
the skin with duration of at least 24 h corresponds to one of the
- average value for the whole group of animals:
Erythemose lesions - 2 or higher
Edematose lesions - 2 or higher
- or lesions equivalent to the average values mentioned above,
calculated for each animal, to 2 animals at least.
It is necessary to use the measure performed in every reading (24, 48,
72 h) of each type of lesion to calculate the respective average values.
A substance is considered corrosive if it produces tissue destruction in
the whole skin thickness, to at least 1 animal. It is considered to
produce burns if tissue lesions in the whole skin thickness appear in an
exposure period no longer than 4 h. If tissue lesions in the whole skin
thickness appear in an exposure period no longer than 3 min, the product
is considered to produce serious burns.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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