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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Acute toxicity for rats and mice of di-2-ethylhexylphthalate with a note upon the mecanism.
Author:
Hodge HC
Year:
1943
Bibliographic source:
Proc Soc Exp Biol Med 53: 20-23

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Single oral administration in rats by intraperitoneal route
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
other: albino
Sex:
not specified
Details on test animals and environmental conditions:
- Weight at study initiation: 149-198g

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
3100, 5700, 12700, 18100, 19200, 23800 mg/kg
No. of animals per sex per dose:
5, 5, 5, 5, 15 and 15 rats in groups treated at 3100, 5700, 12700, 18100, 19200 and 2380 mg/kg respectively.
Control animals:
no
Details on study design:
- Duration of observation period following administration: 5, 7 and 10 days
- Organ were weighted

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 23 800 mg/kg bw
Remarks on result:
other: intraperitoneal
Mortality:
No mortality was observed.
Other findings:
the average liver weights were 8.8, 7.8 and 7.3 g in animals killed 5 days, 7 days and 10 days after the injection, respectively.

Any other information on results incl. tables

Nb of rats Average body weight (g) Dose (mg/kg) Effects
15 198 23800 Diarrhea
15 196 19200 Some diarrhea
5 155 18100  -
5 149 12700 None
5 159 5700 None
5 159 3100 None

Applicant's summary and conclusion

Conclusions:
Under these experimental conditions, the LD50 was estimated to be higher than 23800 mg/kg in rats by the intraperitoneal route.