Registration Dossier
Registration Dossier
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EC number: 204-211-0 | CAS number: 117-81-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study quoted in the EU risk assessment. However, details of the experimental design and original results are not presented in the report.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute and subacute toxicity of di(2-ethylhexyl) phthalate with note upon its metabolism.
- Author:
- Shaffer CB, Carpenter CP
- Year:
- 1 945
- Bibliographic source:
- J. Ind. Hyg. Toxicol. 27, 130-135
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Food and Drug Administration's cuff test
- GLP compliance:
- no
Test material
- Reference substance name:
- Bis(2-ethylhexyl) phthalate
- EC Number:
- 204-211-0
- EC Name:
- Bis(2-ethylhexyl) phthalate
- Cas Number:
- 117-81-7
- Molecular formula:
- C24H38O4
- IUPAC Name:
- 1,2-bis(2-ethylhexyl) benzene-1,2-dicarboxylate
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 20 ml/kg
- No. of animals per sex per dose:
- 6 animals in total
- Control animals:
- not specified
- Details on study design:
- No data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 20 mL/kg bw
- Remarks on result:
- other: = 19800 mg/kg bw
- Mortality:
- 20 ml/kg killed 2 of 6 rabbits.
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008
- Executive summary:
Rabbits were exposed dermally for 24 hours with doses up to 20 ml/kg. That amount killed 2 of 6 rabbits. The LD50 by skin absorption is ca. 20 ml/kg (19800 mg/kg bw).
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