Registration Dossier

Ecotoxicological information

Toxicity to other above-ground organisms

Administrative data

Endpoint:
toxicity to other above-ground organisms
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: 2-d: meets national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
publication
Title:
Correlation of the five test methods to assess chemical toxicity and relation to physical properties.
Author:
Yoshioka Y, Ose Y and Sato T
Year:
1986
Bibliographic source:
Ecotoxicol. Environ. Safety, 12, 15-21.

Materials and methods

Principles of method if other than guideline:
The test organism (Dugesia japonica) collected from a stream was cut into 2 parts and the body part was used for the head regeneration test carried out for 7 days after head cutting. The degree of regeneration was classified as normal, eye spot, tetratophthalmic, anophthalmic, aciphthalmic and death.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material : DEHP
No further details

Sampling and analysis

Analytical monitoring:
not specified

Test substrate

Vehicle:
not specified

Test organisms

Test organisms (species):
other: Dugesia japonica (Planarian)

Study design

Study type:
laboratory study
Total exposure duration:
7 d

Test conditions

Reference substance (positive control):
not specified

Results and discussion

Effect concentrationsopen allclose all
Duration:
7 d
Dose descriptor:
EC50
Effect conc.:
> 1 other: mg/l
Basis for effect:
other: death or head regeneration
Remarks on result:
other: IUCLID4 note: "m" (measured/nominal)
Duration:
7 d
Dose descriptor:
LC50
Effect conc.:
> 1 other: mg/l
Basis for effect:
other: death or head regeneration
Remarks on result:
other: IUCLID4 note: "m" (measured/nominal)

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
In the test conditions, DEHP had no effect on the head regeneration of Dugesia japonica at the highest concentration tested. In consequence, the authors derivated an EC50 above 1 mg/L.