Registration Dossier
Registration Dossier
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EC number: 204-211-0 | CAS number: 117-81-7
Toxicity to other above-ground organisms
Administrative data
- Endpoint:
- toxicity to other above-ground organisms
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2-d: meets national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Correlation of the five test methods to assess chemical toxicity and relation to physical properties.
- Author:
- Yoshioka Y, Ose Y and Sato T
- Year:
- 1 986
- Bibliographic source:
- Ecotoxicol. Environ. Safety, 12, 15-21.
Materials and methods
- Principles of method if other than guideline:
- The test organism (Dugesia japonica) collected from a stream was cut into 2 parts and the body part was used for the head regeneration test carried out for 7 days after head cutting. The degree of regeneration was classified as normal, eye spot, tetratophthalmic, anophthalmic, aciphthalmic and death.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Bis(2-ethylhexyl) phthalate
- EC Number:
- 204-211-0
- EC Name:
- Bis(2-ethylhexyl) phthalate
- Cas Number:
- 117-81-7
- Molecular formula:
- C24H38O4
- IUPAC Name:
- 1,2-bis(2-ethylhexyl) benzene-1,2-dicarboxylate
- Details on test material:
- - Name of test material : DEHP
No further details
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test substrate
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- other: Dugesia japonica (Planarian)
Study design
- Study type:
- laboratory study
- Total exposure duration:
- 7 d
Test conditions
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 7 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 other: mg/l
- Basis for effect:
- other: death or head regeneration
- Remarks on result:
- other: IUCLID4 note: "m" (measured/nominal)
- Duration:
- 7 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 other: mg/l
- Basis for effect:
- other: death or head regeneration
- Remarks on result:
- other: IUCLID4 note: "m" (measured/nominal)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In the test conditions, DEHP had no effect on the head regeneration of Dugesia japonica at the highest concentration tested. In consequence, the authors derivated an EC50 above 1 mg/L.
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