Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-235-6
CAS number: 1314-41-6
Male rats were administered lead acetate in drinking water at
concentrations of 0, 0.25, 0.5, and 1 g/L over 60 days and biochemical
and histopathological analyses were performed on the testes. Body weight
was statistically significantly decreased at all tested doses.
Testicular weight was statistically significantly decreased at 1 g/L.
There were statistically significant increases in blood and testicular
lead concentrations, urinary δ-aminolevulinic acid (ALA), and testicular
cholesterol at all tested doses. There was a statistically significant
decrease in testicular ascorbic acid at all tested doses. There were
statistically significant decreases in seminiferous tubule diameter and
spermatid count at 0.5 g/L and above, and in spermatogenic count and
Leydig cell number and nuclear diameter at 1 g/L. Spermatocytes and
spermatids were in degenerative condition, and the lumen of the
seminiferous tubules was filled with cellular debris at 0.5 g/L. At 1
g/L, the cellular pattern of the seminiferous tubules was disintegrated,
spermatogenic inhibition was at the stage of spermatogonia, and Leydig
cells were in atrophic condition. The reproductive NOAEL and systemic
LOAEL from this study were both 0.25 g/L. The authors stated that high
levels of cholesterol and decreased ascorbic acid along with atrophic
Leydig cells in animals exposed to 1 g/L suggests non-utilization of
cholesterol towards the synthesis of testosterone from Leydig cells.
They concluded that lead may inhibit spermatogenesis at the pre-meiotic
stage via lack of testosterone production from Leydig cells.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Damit Sie die Website optimal nutzen können, verwenden wir Cookies.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again