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EC number: 215-235-6
CAS number: 1314-41-6
Table 1 Body and Kidney Weights of Rats Exposed to One of Several Doses
of lead For indicated Time periods (mean +/-SE)
Table 2 Dose and Time Related Changes in Blood and Kidney Lead
Concentrations, Urinary lead Excretion and Ratio of Excretion to Blood
Values in Rats (mean +/- SE; n = 6 for all values)
* 200 ppm vs 500 ppm; ** 300 ppm vs 1000 ppm; ***500 ppm vs 1000 ppm
Statisitcal Comparisons by ANOVA and Duncan's Multiple range test
Table 3 Tissue Zinc Concentrations in Rats Exposed to lead for 12 weeks
(Mean +/-; Number of Animals in Parentheses)
p<0.01, from controls
***N.D., no observations
Influence of lead on tissue content and urinary excretion of lead, zinc,
and calcium in rats was studied following various exposure periods.
Weanling male rats were fed a trace mineral-sufficient diet with either
0, 200, 500, or 1000 ppm lead (as acetate) in drinking water for 4, 8,
or 12 weeks. Blood lead ranged from 40 to over 100 ug/dl; kidney lead
was highest at 4 weeks. Urinary lead excretion was highest at 4 weeks
and declined with longer exposure. Urinary zinc excretion correlated
positively with lead excretion at the lower excretion rates but
plateaued at higher lead excretion rates. After 12 weeks exposure at
each lead dose employed, decreased zinc concentration was observed in
testis, bone, and brain. Plasma, erythrocyte, and kidney zinc were not
affected, while pancreas and liver zinc were slightly elevated. Urine
calcium was increased significantly only in rats exposed to 1000 ppm
possibly reflecting renal cell damage as determined by elevated renal
calcium levels. These results indicate that lead dose is more important
than exposure period for determining kidney lead levels, while urinary
lead excretion rate is both dose and time dependent. Blood lead
clearance values are relatively independent of dose and fall as exposure
continues. Essential trace metal balance for zinc, especially, and to a
lesser extent for calcium, is affected by the dose and length of chronic
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