Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Toxicity Evaluation of Trisodium Nitrilotriacetate
Author:
Nixon, G.A.
Year:
1971
Bibliographic source:
Toxicol. Appl. Pharmacol. 22, p. 297

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Trisodium Nitrilotriacetate
- Physical state: liquid, aqueuous solution of 20% (w/v) and 50% (w/w)
- no further details

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
20% & 50% no data on volume
No. of animals per sex per dose:
no data

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
254 mg/kg bw
Remarks on result:
other: 50% NA3NTA
Sex:
not specified
Dose descriptor:
LD50
Effect level:
446 mg/kg bw
Remarks on result:
other: 20% Na3NTA

Applicant's summary and conclusion

Conclusions:
The i.p. LD 50 values in rats were found to be 254 mg/kg (50% Na3NTA) and 446 mg/kg (20% Na3NTA). No unusual symptoms were observed in any ot the animals following injection. All surviving animals appeared normal 24 h after dosing. I.p. injection is not considered relevant for human hazard assessment.