Registration Dossier
Registration Dossier
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EC number: 225-768-6 | CAS number: 5064-31-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity Evaluation of Trisodium Nitrilotriacetate
- Author:
- Nixon, G.A.
- Year:
- 1 971
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 22, p. 297
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Trisodium nitrilotriacetate
- EC Number:
- 225-768-6
- EC Name:
- Trisodium nitrilotriacetate
- Cas Number:
- 5064-31-3
- Molecular formula:
- C6H9NO6.3Na
- IUPAC Name:
- trisodium 2-[bis(carboxylatomethyl)amino]acetate
- Details on test material:
- - Name of test material (as cited in study report): Trisodium Nitrilotriacetate
- Physical state: liquid, aqueuous solution of 20% (w/v) and 50% (w/w)
- no further details
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 20% & 50% no data on volume
- No. of animals per sex per dose:
- no data
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 254 mg/kg bw
- Remarks on result:
- other: 50% NA3NTA
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 446 mg/kg bw
- Remarks on result:
- other: 20% Na3NTA
Applicant's summary and conclusion
- Conclusions:
- The i.p. LD 50 values in rats were found to be 254 mg/kg (50% Na3NTA) and 446 mg/kg (20% Na3NTA). No unusual symptoms were observed in any ot the animals following injection. All surviving animals appeared normal 24 h after dosing. I.p. injection is not considered relevant for human hazard assessment.
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