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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and accptable for assessment
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report Date:
1966

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not specified
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report):CP56453, Monsanto Sample no. 173
- Physical state: solid
- Other: no detailed data provided

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
water
Duration of exposure:
24 h
Doses:
500, 1000, 2000 mg/kg bw. as a 10% aqueous solution
No. of animals per sex per dose:
1/1
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD0
Effect level:
2 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The highest application of 2000 mg/kg bw was found to be non-lethal by skin absorption in male and female rabbits.
Executive summary:

In an acute dermal toxicity study three male and female rabbits were dermally exposed to Na3NTA in water (10 % aqueous solution) for 24 hours at doses of 500, 1000, and 2000 mg/kg bw.

No mortality occurred – not even at highest concentration of 2000 mg/kg bw.

According to expert judgment trisodium nitrilotriacetate practically non-toxic by skin absorption. There were no symptoms of systemic toxicity observed. No weekness or loss of appetite. Since there was no death, no autopsies were performed.