Registration Dossier
Registration Dossier
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EC number: 215-127-9 | CAS number: 1304-28-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin
The potential of barium oxide to cause dermal corrosion was assessed by a single topical application of 500 μL of the test substance to the Corrositex® Biobarrier Membrane (Corrositex® assay). The Corrositex® Biobarrier Membrane is a test system consisting of a reconstituted collagen matrix. The assay is based on the time that is required for the test substance to penetrate through the Corrositex® Biobarrier Membrane and produce a change in the Chemical Detection System (CDS). In addition to the test substance a positive and a negative control were assessed. The Corrositex® assay showed the following results: The qualification screen demonstrated that the test substance is able to react with the CDS and produce a visible color change. A timescale category test was carried out to distinguish between weak and strong acids or bases. The test substance was assigned to timescale category 1 (having a high acid/alkaline reserve). In the main test four Corrositex® Biobarrier Membranes were treated with the undiluted test substance. The mean break through time of the test substance, determined in the actual Corrositex® assay, was 17 minutes and 16 seconds.
Eye
No data available.
Effects on skin irritation/corrosion: corrosive
Justification for classification or non-classification
A Corrositex® assay conducted according to OECD Guideline 435 (BASF SE 2015) shows a corrosive potential of barium oxide. Based on the results of the assay, the test substance is classified as be corrosive to the skin, category 1B (H314) according to Regulation (EC) No 1272/2008 (CLP).
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