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Diss Factsheets
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EC number: 215-127-9 | CAS number: 1304-28-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Read-across from barium chloride for barium toxicity. Study does not give information on the dose levels tested and the mortality rates at different dosages.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Subchronic Oral Toxicity of BaCl2 in Rats
- Author:
- Tardiff et al
- Year:
- 1 980
- Bibliographic source:
- Journal of Environmental Pathology and Toxicology, 4:267-275
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- no specification of dose levels, no data on fasting of animals prior to compound administration, no data on clinical examinations or necropsy results, no specification of mortality at different dose levels
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Barium chloride
- EC Number:
- 233-788-1
- EC Name:
- Barium chloride
- Cas Number:
- 10361-37-2
- IUPAC Name:
- barium dichloride
- Details on test material:
- - Name of test material (as cited in study report): Barium Chloride
- Molecular formula (if other than submission substance): BaCl2
- Physical state: solid
- Analytical purity: at least 98%
- Impurities (identity and concentrations): no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- rats were used both as weanlings (21-25 days of age) and as adults (60-70 days)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 8 doses (concentrations of compound were not specified) were administered as single doses by gavage
- No. of animals per sex per dose:
- 10 animals per dose level
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 132 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 112.2 - 162.36
- Remarks on result:
- other: LD50 and 95% CL were calculated for Barium
Any other information on results incl. tables
LD50 for weanling rats was higher than for adults (220 mg Barium/kg, 95% CL 186,6 -264 and 132 mg Barium/kg, 95% CL 112.2 -162.4, respectively). No explanation for this finding was provided.
A dose-mortality curve was provided and showed a slope of 7.2 for adult animals and 6.2 for weanlings.
Applicant's summary and conclusion
- Executive summary:
Although the study does not provide information on the dose levels tested and the mortalities at different dose levels, it can provide LD50 values with 95% confidence intervals and the slope of a dose-mortality curve. The data are in accordance with the literature (ref. Borzelleca et al., 1988), therefore the data provided is considered sufficient for proposal of classification.
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