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Diss Factsheets
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EC number: 208-704-1 | CAS number: 538-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Dicyclohexylcarbodiimide identification
- Author:
- Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA)
- Year:
- 2 012
- Bibliographic source:
- Gestis data base
Materials and methods
- Principles of method if other than guideline:
- Not known
- GLP compliance:
- not specified
- Type of study:
- not specified
Test material
- Reference substance name:
- Dicyclohexylcarbodiimide
- EC Number:
- 208-704-1
- EC Name:
- Dicyclohexylcarbodiimide
- Cas Number:
- 538-75-0
- Molecular formula:
- C13H22N2
- IUPAC Name:
- N,N'-dicyclohexylcarbodiimide
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Results and discussion
Any other information on results incl. tables
Sensitizing actions of DCC to humans were demonstrated by several well-documented cases, in particular concerning accidental contamination of the skin.
In an experiment recently carried out on various strains of mice (mouse ear swelling test), the maximum non-irritative concentration (0.1 % solution in acetone) and the minimum irritative concentration (0.3 %) were initially tested on both sides of the outer ear. These concentrations were independent of the animal strain used. The following examination of the potential to sensitize provided distinct
differences for the sensitivity of the strains which were genetically related (dependent on the haplotype). Cross reactivity for DCC could be detected only on animals sensitized to diisopropylcarbodiimide.
It was derived from a further study on mice that physical stress (here: limitation of movement) can decrease the "threshold concentration" for sensitization.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance is officially classified as skin sensitiser.
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