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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
secondary source
Title:
Dicyclohexylcarbodiimide identification
Author:
Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA)
Year:
2012
Bibliographic source:
Gestis data base

Materials and methods

Principles of method if other than guideline:
Not known
GLP compliance:
not specified
Type of study:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

In vivo test system

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Results and discussion

Any other information on results incl. tables

Sensitizing actions of DCC to humans were demonstrated by several well-documented cases, in particular concerning accidental contamination of the skin.

In an experiment recently carried out on various strains of mice (mouse ear swelling test), the maximum non-irritative concentration (0.1 % solution in acetone) and the minimum irritative concentration (0.3 %) were initially tested on both sides of the outer ear. These concentrations were independent of the animal strain used. The following examination of the potential to sensitize provided distinct

differences for the sensitivity of the strains which were genetically related (dependent on the haplotype). Cross reactivity for DCC could be detected only on animals sensitized to diisopropylcarbodiimide.

It was derived from a further study on mice that physical stress (here: limitation of movement) can decrease the "threshold concentration" for sensitization.

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance is officially classified as skin sensitiser.