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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
other: data from peer-reviewed handbook
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2004

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Data from peer reviewed handbook. No information provided on methods.
GLP compliance:
no
Remarks:
reference dated 6-14-63.
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
corn oil
Remarks:
undiluted, 10% or 1% in corn oil.
Doses:
2.5 - 3200 mg/kg
No. of animals per sex per dose:
31 rats.
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: up to 5 days.
- Other examinations performed: clinical signs, body weight.

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
10 mg/kg bw
Based on:
not specified
Mortality:
Deaths reported at 1/2 h - 3 days.
Clinical signs:
Slight to moderate weakness; after 24h, abdominal distension, tremor, not eating, labored respiration, cyanosis.

Applicant's summary and conclusion

Conclusions:
The acute intraperitoneal LD50 in rats was 10 mg/kg.
Executive summary:

According to 'Sax’s Dangerous Properties of Industrial Materials. 11th ed. (2004)' (peer reviewed handbook data), the test item has an acute intraperitoneal LC50 of 10 mg/kg in rats.