Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation
Remarks:
no data
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
secondary source
Title:
Dicyclohexylcarbodiimide identification
Author:
Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA)
Year:
2012
Bibliographic source:
Gestis data base - Projektgebundene Literaturliste Nr. 1

Materials and methods

Principles of method if other than guideline:
no Guideline cited in the report.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Results and discussion

Any other information on results incl. tables

Examination of rabbits' eyes after exposure to the dry solid (crystals) for one hour resulted in slight through to moderate reddening of the lids, nictitating membrane and conjunctiva. After 24 hours there was slight intensification of the reddening and discoloration of the cornea and after 48 hours moderate reddening, slight edema and injection (of blood vessels) into the iris were observed.

14 days later, changes to the conjunctiva, cornea (opacity) and nictitating membrane were no longer noticeable. The lids were still

thickened, sometimes scarred and the surrounding of the eyes was depilated.

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance is officially classified as eye irritant.