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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
secondary source
Title:
Dicyclohexylcarbodiimide - identification
Author:
Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA)
Year:
2012
Bibliographic source:
Gestis Substance Database - Projektgebundene Literaturliste Nr. 1

Materials and methods

Principles of method if other than guideline:
Not available
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified

Results and discussion

Any other information on results incl. tables

In a dermal test on guinea pigs, 1 drop of the neat substance (probably of the molten substance) caused massive reddening and moderate formation of edema within 24 hours which persisted for a further 24 hours. The reddening was still moderately pronounced following 1 week, the edema were diminished. After 2 weeks there was only still slight reddening but complete hair loss.

In experiments on further guinea pigs, a few drops (probably of the molten mass) caused death after less than 24 hours (LD50 value smaller than 0.1 ml/kg bw). In general, the substance was described as moderately through to severely irritating to the skin and absorbable through the skin.

Applicant's summary and conclusion

Interpretation of results:
toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance is officially classified as toxic in contact with skin.