Registration Dossier
Registration Dossier
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EC number: 225-059-1 | CAS number: 4635-59-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meetd basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- 4653-59-0
- IUPAC Name:
- 4653-59-0
- Details on test material:
- Name of the test substance used in the study report: 4-Chlorbuttersäurechlorid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- Fasting period: 15 - 20 h before administration
Application volume: 5 ml/kg - Doses:
- 215, 1000, 1470, 2150, 4640 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: after 2-4 d, 7 d and 13 d
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 350 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 500 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 210 mg/kg bw
- Mortality:
- Male animals:
215, 1000 mg/kg: no mortalities after 14 days
1470 mg/kg: 2/5 after 14 days
2150 mg/kg and 4640 mg/kg: all animals within 14 days
Female animals:
215 mg/kg: no deaths after 14 days
1000 mg/kg: 1/5 after 14 days
1470 mg/kg: 4/5 after 14 days
2150 and 4640 mg/kg: all animals died within 14 days - Clinical signs:
- other: 1000, 1470, 2150 and 4640 mg/kg: dyspnea, apathy, abnormal position, staggering, atonia, pain reflexes missing, narcotic-like state, tremor, ruffled fur, exsiccosis, paresis, poor general state.
- Gross pathology:
- Animals that died: acute dilatation of the heart atrium; acute congestive hyperemia; liver: manifold slightly broadened peripheral lobule painting; stomach: manifold hemorrhagic corrosive scab formation; intestine: diffuse reddened mucosa.
Sacrificed animals - up to 1000 mg/kg: no abnormalities. 1470 mg/kg: stomach: top of the gastro-esophageal vestibule partly thickened and partly button formation; adhesions of the forestomach with the spleen, liver and peritoneum.
Applicant's summary and conclusion
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