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Diss Factsheets
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EC number: 695-022-6 | CAS number: 473278-76-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 Nov - 10 Dec 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: “Test on Hydrolyzability” of agricultural chemicals stipulated in the “Notification Concerning Test Data for Registration of Agricultural Chemicals” (12 Nohsan No. 8147)
- Version / remarks:
- November 24, 2000, revised on December 10, 2002
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: The test solution was quantitatively analyzed at each measurement point
- Sampling intervals/times for pH measurements: Days 0 and 5 - Buffers:
- pH 4: 2 ml of 0.1 N sodium hydroxide was added to 250 mL of 0.1 M potassium hydrogen phthalate and the volume was adjusted to 500 mL with purified water.
pH 7: 148 mL of 0.1 N sodium hydroxide was added to 250 mL of 0.1 M potassium dihydrogen phosphate and the volume was adjusted to 500 mL with purified water.
pH 9: 106 mL of 0.1 N sodium hydroxide was added to 250 mL of 0.1M boric acid and the volume was adjusted to 500 mL with purified water. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: Glass-stoppered Erlenmeyer flask (100 mL capacity, glass)
- Sterilisation method: use of an autoclave
- Measures to exclude oxygen: Nitrogen gas was bubbled through each buffer solution for 5 minutes to expel dissolved oxygen
TEST MEDIUM
- Volume used/treatment: 100 mL
- Preparation of test medium: The test substance stock solution (2.50 mL) was withdrawn and diluted with the buffer solution of desired pH to prepare the test solution (250 mL) - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 100 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 100 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 100 mg/L
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- no
- Transformation products:
- not measured
- % Recovery:
- 94.3
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- other:
- Remarks:
- Total recovery of test substance: 101%
- % Recovery:
- 100
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Details on results:
- TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: Yes/
Reference
Description of key information
The test substance was shown to be hydrolytically stable at pH 4, 7, and 9 (DT50: > 1 year at 25 °C).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
The available study, following GLP and OECD Guideline 111, assessed the hydrolytic degradation of the test substance at 25 °C and under alkaline (pH 9), neutral (pH 7) and acidic (pH 4) conditions. A preliminary hydrolysis test was performed at 50 °C in aqueous solution at pH 4, 7 and 9. The mean residual rate of the test substance was at least 90% at all pH levels under the test conditions used in the present study (50 °C, 5 days). Therefore, the test substance was shown to be hydrolytically stable (DT50 (25 °C) > 1 year). On the basis of the results from the preliminary test, no further work was conducted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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