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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2005
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Directive 92/69 B.3 (OECD 402)
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
457-830-5
EC Name:
-
Cas Number:
2557-13-3
Molecular formula:
Hill formula: C9 H7 F3 O2
IUPAC Name:
Methyl, 3-Trifluoromethylbenzoate

Test animals

Species:
other: Rat Wistar
Strain:
Wistar
Sex:
male/female

Administration / exposure

Type of coverage:
semiocclusive
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
No dermal reaction were observed during the course of the
study
Gross pathology:
Effects on organs:
No organ or tissue gross findings were seen during clinical
examination.
Other findings:
Signs of toxicity (local):
No clinical signs were observed during the course of the
study.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU