Registration Dossier
Registration Dossier
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EC number: 457-830-5 | CAS number: 2557-13-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EEC B1 tris (OECD 423)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 457-830-5
- EC Name:
- -
- Cas Number:
- 2557-13-3
- Molecular formula:
- Hill formula: C9 H7 F3 O2
- IUPAC Name:
- Methyl, 3-Trifluoromethylbenzoate
Constituent 1
Test animals
- Species:
- other: Rat Wistar CrlGIxBrlHan:WI
- Strain:
- Wistar
Administration / exposure
- Vehicle:
- other: Olive oil Ph.Eur./DAB
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Mortality:
- Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 3
Female: 300 mg/kg bw; Number of animals: 3; Number of deaths: 0 - Clinical signs:
- Signs of toxicity related to dose levels:
Clinical observation in the 2000 mg/kg administration group
revealed impaired and poor general state, dyspnoea,
staggering and smeared fur and were observed from hour 1
until including study day 1 after administration.
No clinical signs and findings were observed in the 300
mg/kg administration during clinical examination. - Gross pathology:
- Effects on organs:
During necropsy the animals (2000 mg/kg, 3 females) that
died comprised a moderate post mortal state, few to many
black erosion /ulcers in the glandular stomach and a red
discoloration of the contents fo the urinary bladder. One
animal showed no macroscopic pathologic abnormalities.
No macroscopic pathologic abnormalities were seen in the
animals examinated at termination of the study (300 mg/kg, 6
females).
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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