Registration Dossier
Registration Dossier
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EC number: 203-560-6 | CAS number: 108-20-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1938
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Significant methodological deficiencies, information in published paper is insufficient
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 938
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- other: liquid
- Details on test material:
- - Physical state: Liquid
- Analytical purity: Commercial grade with 3% isopropyl alcohol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- The material was continuously dripped onto the shaved skin to keep it wet for one hour, while continuously evaporating.
- Doses:
- Approximately 150 ml of material was used over the course of the hour.
- No. of animals per sex per dose:
- 1 animal
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: LD50 reported by HPV (2008), no LD50 reported by study authors
Any other information on results incl. tables
The procedure resulted in no general ill effect.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: CLP (EC 1272/2008)
- Conclusions:
- The procedure resulted in no general ill effect upon dermal exposure. LD50 of > 2000 mg/kg body weight reported by HPV (2008), no LD50 reported by study authors.
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