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EC number: 203-311-1 | CAS number: 105-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No information was given concerning the gender of the animals. The description of the conducted methods was not layed out in detail in Salaman 1956, but were only referred to in another publication (Roe 1955).
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- FURTHER TESTS FOR TUMOUR-INITIATING ACTIVITY: N,N-DI-(2-CHLOROETHYL)-P-AMINOPHENYLBUTYRIC ACID (CB1348) AS AN INITIATOR OF SKIN TUMOUR FORMATION IN THE MOUSE
- Author:
- Salaman, M.H., and Roe, F.J.C.
- Year:
- 1 956
- Bibliographic source:
- Br. J. Cancer 10, 363-378
- Reference Type:
- publication
- Title:
- FURTHER STUDIES ON INCOMPLETE CARCINOGENESIS: TRIETHYLENE MELAMINE (T.E.M.), 1,2-BENZANTHRACENE AND ,3-PROPIOLACTONE, AS INITIATORS OF SKIN TUMOUR FORMATION IN THE MOUSE
- Author:
- Roe, F.J.C, and Salaman, M.H.
- Year:
- 1 955
- Bibliographic source:
- Br. J. Cancer 9, 177-203
- Reference Type:
- review article or handbook
- Title:
- No information
- Author:
- BG Chemie
- Year:
- 1 994
- Bibliographic source:
- Toxicological Evaluations 7: Potential Health Hazards of Existing Chemicals, 7.7 Carcinogenicity, p.40, 1994, BG Chemie, Springer Verlag, ISBN 3-540-57300-3
Materials and methods
- Principles of method if other than guideline:
- Method: other: subacute dermal toxicity
- GLP compliance:
- no
Test material
- Reference substance name:
- Diethyl carbonate
- EC Number:
- 203-311-1
- EC Name:
- Diethyl carbonate
- Cas Number:
- 105-58-8
- Molecular formula:
- C5H10O3
- IUPAC Name:
- diethyl carbonate
- Details on test material:
- Name of the test substance as stated in the publication: Diethyl carbonate
purchased from: Professor F. Bergel (of the Chester Beatty Research Institute) kindly supplied the test substance
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: strain "S"
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- not specified
- Frequency of treatment:
- thrice per week, in total 10 applications
Doses / concentrations
- Dose / conc.:
- 2.9 other: g/kg bw/day (nominal)
- Remarks:
- Doses / Concentrations:
Basis: per animal dose of pure substance diethyl carbonate
- No. of animals per sex per dose:
- 25 animals (no information on sex distribution)
- Control animals:
- other: yes, 0.17 % croton oil in acetone
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- LOAEL
- Effect level:
- 48.3 - 145 other: g/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- gross pathology
- mortality
- Remarks on result:
- other:
- Remarks:
- Treated animals: of the 25 animals, 2 animals with tumours (papillomas), 2 other animlas died
- Dose descriptor:
- dose level: control group
- Effect level:
- 0 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- gross pathology
- mortality
- Remarks on result:
- other:
- Remarks:
- Control group (0.17 % croton oil in acetone): of 20 animals, 3 animals died, no animals with tumours (papillomas)
Target system / organ toxicity
- Critical effects observed:
- not specified
- Lowest effective dose / conc.:
- 48.3 other: g/kg bw/day (nominal)
- System:
- other: papillomas, tumours, lethality
Any other information on results incl. tables
2 animals died during the subacute dermal treatment with 2.9 g of the pure test substance diethylcarbonate. Two surviving animals showed tumours at the end of the croton oil treatment. In the corresponding control group (0.17 % croton oil only) all animals survived and no animal beared any tumours (papillomas).
Applicant's summary and conclusion
- Conclusions:
- Dermal application of the test substance diethylcarbonate to the clipped backs of mice (10 applications in total, thrice a week) resulted in 2 dead animals and 2 further animals with tumours (papillomas) (total of 25 animals). In the control group 17 mice survived, and none had tumours. In the review of BG Chemie (1994) was stated "In another control group which underwent comparable treatment with croton oil, 4/19 mice had papillomas. The results of the study were evaluated as negative by the authors (Salaman and Roe, 1956).". In the opinion of the author of this IUCLID dossier the results on the repeated dose toxicity (dermal) cannot be concluded as absolutely negative as two animals died and two showed tumors. Therefore a toxic effect of the test substance diethyl carbonate cannot be excluded completely. It should also be remarked when evaluating the above mentioned data that therein definitions and distinctions of "papillomas" and "tumours" are not fully clear.
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