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EC number: 203-093-8 | CAS number: 103-26-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: pre-guideline study but performed fulfilling basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- yes
- Remarks:
- Modified Challenge with intradermal and occlusive application
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- Methyl cinnamate
- EC Number:
- 203-093-8
- EC Name:
- Methyl cinnamate
- Cas Number:
- 103-26-4
- Molecular formula:
- C10H10O2
- IUPAC Name:
- methyl 3-phenylacrylate
- Test material form:
- other: solid, applied as solution
- Details on test material:
- no details provided on test material in report
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- other: water, Freund's Complete Adjuvant (FCA) and petrolatum
- Concentration / amount:
- Induction: 2 intradermal injections of 5% aqueous solution and 2 5%solutions in Freunds' Complete Adjuvant (each 0.1 ml) and 25% in petrolatum on day 8 occlusive for 2 days (total dose 20 mg intradermally plus 250 mg epicutaneously)
Challenge: On day 21 with 25% in petrolatum occlusive for 24 hours.
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: water, Freund's Complete Adjuvant (FCA) and petrolatum
- Concentration / amount:
- Induction: 2 intradermal injections of 5% aqueous solution and 2 5%solutions in Freunds' Complete Adjuvant (each 0.1 ml) and 25% in petrolatum on day 8 occlusive for 2 days (total dose 20 mg intradermally plus 250 mg epicutaneously)
Challenge: On day 21 with 25% in petrolatum occlusive for 24 hours.
- No. of animals per dose:
- 5 animals
- Details on study design:
- On day 0, the animals were injected intradermally with 0.1 ml of a 5% solution of the compound, with 0.1 ml of a 5% emulsion of the compound in FCA and with 0.1 ml of FCA alone, each injection was given twice. In addition, on day 8 the compound, dissolved in petrolatum up to 25%, was applied to a clipped skin area of the neck and kept under occlusive bandage for 2 days (total dose 20 mg intraderzzally plus 250 mg epicutaneously).0n day 21, an occlusive patch test with the compound in petrolatum was applied to the flank for 24 hours and the reactions were read 24 and 48 hours after removing the patch.
- Positive control substance(s):
- no
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- other: 1st (24h after challenge) and 2nd (48 after challenge) reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 25% solution
- No. with + reactions:
- 3
- Total no. in group:
- 5
- Remarks on result:
- other: Reading: other: 1st (24h after challenge) and 2nd (48 after challenge) reading. . Hours after challenge: 48.0. Group: test group. Dose level: 25% solution. No with. + reactions: 3.0. Total no. in groups: 5.0.
- Reading:
- rechallenge
- Hours after challenge:
- 144
- Group:
- test chemical
- Dose level:
- 25%
- No. with + reactions:
- 4
- Total no. in group:
- 5
- Remarks on result:
- other: Reading: rechallenge. . Hours after challenge: 144.0. Group: test group. Dose level: 25%. No with. + reactions: 4.0. Total no. in groups: 5.0.
Any other information on results incl. tables
Authors conclusion: 60% of the animals show positive test reactions 24 h and 48 h after removing the occlusive challenge patch. Furthermore, epicutaneous tests one week later are positive in 4/5 of the guinea pigs.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The treatment with methyl cinnamate causes sensitization in about 60% (first and second reading) and 80% (rechallenge) of the guinea pigs in the Maximization test.
- Executive summary:
In this Maximization test (intradermal induction and occlusive challenge) 4 out of 5 animals showed positive reaction following rechallenge.
Thus, in this test methyl cinnamate is considered a skin sensitizer.
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