Registration Dossier
Registration Dossier
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EC number: 203-093-8 | CAS number: 103-26-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No bioaccumulation is expected; oral and dermal absorption is estimated being complete (100%) whereas inhalative absorption is considered negligible.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
Additional information
Methyl cinnamate is expected to be completely absorbed via oral (assumed 100%) and dermal route (assumed 100% as the worst case since there is lack of available data) while the inhalation exposure can be seen negligible. Methyl cinnamate is rapidly hydrolyzed mainly into cinnamic acid and methanol after absorption. Cinnamic acid is widely distributed in blood, with little retention in tissues. Cinnamic acid, was nearly complete excreted by a maximum of 72 hours in urine and to a minor extent in faeces mainly in form of conjugated metabolites (i.e. hippuric acid and benzoylglucuronide) or free cinnamic acid.
The methanol liberated in the rapid hydrolysis of methyl cinnamate will be mainly metabolized to the corresponding aldehyde and acid. Distribution is rapid and occurs throughout body water. Elimination of methanol from blood via urine and exhaled air and by metabolism is efficient but slow compared to ethanol.
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