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Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

14.09.2018 - 29.09.2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Specific details on test material used for the study:

Test Item Name TYZOR AC 436
IUPAC Name Citric acid titanium salt
C.A. Name Information not provided by Sponsor
CAS Number (EC # 923-927-0)
Batch/Lot Number 334-301300/000005
Analysed Purity (Provided by Sponsor) As Ti: 4.9% w/w (Refer Certificate of Analysis in APPENDIX 3)
Appearance Yellow to brownish clear liquid
Manufactured by Dorf Ketal Speciality Catalyst Private Limited
Supplied to JRF by Dorf Ketal Speciality Catalyst Private Limited
Date of Manufacture September 2017
Date of Expiry September 2019

Key result

Water solubility:

> 1 000 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

>= 5 - <= 9

Conclusions:

 The solubility of TYZOR ACtivate 422in all the buffer waters[viz. pH 5, 7 and 9],was > 1000 g/L at 20 °C.

Executive summary:

Owing to extremely high solubility of the test item in all three buffer waters [viz. pH 5, 7 and 9], observed in the preliminary test, five times higher quantities of test item were weighed (0.5010 g for pH 5, 0.5006 g for pH 7 and 0.5019 g for pH 9)and transferred into three separate beakers and 0.1 mL of respective buffer water was added to the respective beaker. It was observed that the test item even got miscible in all the buffer waters at five times higher quantity.

Hence, saturation of test item in buffer waters that is essential in the “Shake Flask Method”, could not be achieved. Therefore, the experiment was stopped at this stage and no further analysis was carried out and the solubility of TYZOR AC 436 was reported as > 1000 g/L at 20 °C in all the buffer waters.

Description of key information

Water Solubility (TYZOR AC 436; OECD 105): > 1000 g/L at 20 °C

Key value for chemical safety assessment

Water solubility:

1 000 g/L

at the temperature of:

20 °C

Additional information

Owing to extremely high solubility of the test item in all three buffer waters [viz. pH 5, 7 and 9], observed in the preliminary test, five times higher quantities of test item were weighed (0.5010 g for pH 5, 0.5006 g for pH 7 and 0.5019 g for pH 9)and transferred into three separate beakers and 0.1 mL of respective buffer water was added to the respective beaker. It was observed that the test item even got miscible in all the buffer waters at five times higher quantity. Hence, saturation of test item in buffer waters that is essential in the “Shake Flask Method”, could not be achieved. Therefore, the experiment was stopped at this stage and no further analysis was carried out and the solubility of TYZOR AC 436 was reported as > 1000 g/L at 20 °C in all the buffer waters.