Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Allergic contact dermatitis from N-(cyclohexlthio)phthalimide in a playground fitter
Author:
Loffeld A and Foulds IS
Year:
2004
Bibliographic source:
Contact Dermatitis 51, 212-213

Materials and methods

Study type:
clinical case study

Test material

Constituent 1
Chemical structure
Reference substance name:
3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate
EC Number:
223-861-6
EC Name:
3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate
Cas Number:
4098-71-9
Molecular formula:
C12H18N2O2
IUPAC Name:
5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane

Results and discussion

Any other information on results incl. tables

RS-Freetext:
Positve reactions were observed on days 2 and 4 with
- cyclohexylthiophthalimide (1 % pet.)
- isophoronediisocyanate (no details reported).
He subsequently avoided contact with the rubber material and his symptoms  have cleared.

Applicant's summary and conclusion