Registration Dossier
Registration Dossier
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EC number: 200-680-0 | CAS number: 68-19-9
Endpoint summary
Administrative data
Description of key information
Supporting study: A 16 year-old-female was tested for skin sensitization to Cyanocobalamin. After having suffered diverse reactions to mixture of Cyanocobalamine plus benzyl alcohol, the patient did not showed any reaction to the intranasal application of 500µg of Cyanocobalamin alone.
Additional information
Supporting study: A 16 -year-old female was referred for assessment of possible anaphylactic reactions following Cyanocobalamin injections. After the first intramuscular injection she reported pain at the injection site. In the second exposition, 2 months later, she also reported sensation of subesternal burning and pleuritic pain. In the third exposition, 1 month later, she added pruritus of the arms and legs. Firstly she was skin tested to three commercial preparations of injectable cyanocobalamin and to the benzyl alcohol (0.9%) preservative found in each. Prick testing was negative, but intradermal testing was positive in all cases.
Then, she was given a 500µg dose of a cyanocobalamin gel (without benzyl alcohol) for intranasal application. The patient did not demonstrated any reaction, and therefore Cyanocobalamin can be considered as non sensitizer under the test conditions.
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