Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-680-0
CAS number: 68-19-9
Table 1. Data Concerning Experimental
Administration of Vitamin B12.
Route of Injection
Amount of Vitamin B12 (mg/kg)
Signs of Toxicity
Excitatory state with convulsions
Excitatory state with convulsions ending in cardiac and respiratory failure
Forty albino mice were given intraperitoneal injections of the test
substance in doses of 0.75, 1.5 and 3 mg/kg and 3 mg/kg of the test
substance subcutaneously.On the basis of the study findings, it can be
stated that an intraperitoneal dose of 0.75 mg/kg is devoid of toxicity,
while an intraperitoneal dose of 1.5 mg/kg is toxic, causing excitation
and convulsions to the exposed animals. The highest dose tested (3
mg/kg) is lethal for 100 per cent of the animals treated, administered
either intraperitoneally or subcutaneously. Mice that died after
injection of Vitamin B12 showed no pathologic changes other than
congestion of the lung. From these findings, the intraperitoneal and
subcutaneous LD100 of the test substance is determined to be 3 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again