Registration Dossier
Registration Dossier
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EC number: 202-874-0 | CAS number: 100-64-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The growth inhibiting effect of Cyclohexanone oxime on algae was tested with Desmodesmus subspicatus according to German Industrial Standard DIN 38412, part 9, which is identical to ISO 8692 and similar to OECD 201 (reliability category 2). The exposure duration was 96 h.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 18.2 mg/L
- EC10 or NOEC for freshwater algae:
- 1.1 mg/L
Additional information
The growth inhibiting effect of Cyclohexanone oxime on algae was tested with Desmodesmus subspicatus (reported as: Scenedesmus subspicatus) according to German Industrial Standard DIN 38412, part 9, which is identical to ISO 8692 and similar to OECD 201. The exposure duration was 96 h. No analytical monitoring was performed (reliability category 2). The determined effect values are: EC10 (96 h, growth rate) = 1.055 mg/L (95% CI: 0.20 -5.50);
EC50 (72 h, growth rate) = 18.24 mg/L.
No influence of the test item on photosynthesis capacity after 96 hours was observed (Control 30%; treatment groups 28% to 36%). No self fluorescence and no pH effect of the test item was observed. The validity criteria of the guideline were met.
This is supported by a study summary on toxicity of cyclohexanone oxime towards aquatic algae (study owner: Ministry of the Environment Japan) available from J-Check, an internet resource from National Institute of Technology and Evaluation (NITE) Japan (RL4, as no original study report available). The study was conducted according to OECD 201 and compliant to GLP. In the database however only the most essetial data are given. The follwoing 72 hour (no)effect concentrations were reported relating to growth rate of algae:
EC50 (72 h; growth rate) = 9.8 mg/L
NOEC (72 h; growth rate) = 0.95 mg/L
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