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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23. Jan 1979 to 26. Jan 1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Similar to guideline OECD 404 with acceptable restrictions, limited documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
other: EPA guideline (not further specified)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
Observation period only up to 48 h after end of exposure
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexanone oxime
EC Number:
202-874-0
EC Name:
Cyclohexanone oxime
Cas Number:
100-64-1
Molecular formula:
C6H11NO
IUPAC Name:
cyclohexanone oxime
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): cyclohexanone oxime
- Substance type: white crystalline powder
- Storage condition of test material: at room temperature

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Bunnyville Farm, Littlestown, USA
- Housing: individually
- Diet (ad libitum): Purina rabbit chow
- Water (ad libitum): automated water supply

Test system

Type of coverage:
other: covering by polyethylene tubing and elastic bandage
Preparation of test site:
other: 4 shaved application sites per animal, two of it abraded
Vehicle:
other: application sites were premoistened with physiological saline before application of the test substance
Controls:
no
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g per application site
Duration of treatment / exposure:
24 h
Observation period:
up to 72 h after application (48 h after end of exposure)
Number of animals:
6
Details on study design:
TEST SITE
- Area of exposure: one square inch
- % coverage: 100
- Type of wrap if used: gauze patch held in place with transparent tape, fixed by a nonabsorbent binder composed of polyethylene tubing and elastic bandage

REMOVAL OF TEST SUBSTANCE
- Washing (if done): substance was wiped off (no further details)

SCORING SYSTEM: according to Draize

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 and 72 h after application (0 or 48 h after end of exposure)
Score:
0
Max. score:
4
Reversibility:
other: no effects observed
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 and 72 h after application (0 or 48 h after end of exposure)
Score:
0
Max. score:
4
Reversibility:
other: no effects observed
Irritant / corrosive response data:
No irritating effects were observed neither for intact nor abraded skin

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the conditions of this study, the test substance was not irritating
Executive summary:

Six New Zealand white rabbits were exposed dermally to the test substance according to EPA guidelines (similar to guideline OECD 404). 0.5 g of test item were applied to four shaved application sites per animal, two of which were abraded. After 24 h of exposure the substance was wiped off and the effects evaluated at 24 and 72 h after application. No erythema or edema were observed at any time point, neither on intact nor on abraded skin. Under the conditions of this study, the test substance was not irritating to the skin of rabbits.