Registration Dossier
Registration Dossier
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EC number: 201-170-0 | CAS number: 79-03-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Propionyl chloride
- EC Number:
- 201-170-0
- EC Name:
- Propionyl chloride
- Cas Number:
- 79-03-8
- Molecular formula:
- C3H5ClO
- IUPAC Name:
- propanoyl chloride
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Kisslegg
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 50, 64, 80, 100, 125, 160, 200 and 1600 mm3/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 and 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 96 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value is 90 mm3/kg
- Mortality:
- 50 mm3/kg: no deaths after 7 days (no recordings after 14 days)
64 mm3/kg: 4/10 males and 2/10 females after 7 days and 6/10 males and 2/10 females after 14 days
80 mm3/kg: 1/10 males and 3/10 females after 7 days and 4/10 males and 4/10 females after 14 days
100 mm3/kg: 7/10 males and 8/10 females after 7 days and 8/10 males and 8/10 females after 14 days
125 mm3/kg: 10/10 males and 6/10 females after 7 days and all animals died after 14 days
160 and 1600 mm3/kg: all animals died after 7 days
200 mm3/kg: 10/10 males and 8/10 females after 7 days (no recordings after 14 days) - Clinical signs:
- Dyspnoea, shakiness, convulsions, cramps, staggering and lying on the stomach
- Body weight:
- Normal body weight growth
- Gross pathology:
- Cauterization and intraabdominal adhesions
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
